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4rz4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Fructose-6-phosphate aldolase Q59E Y131F from E.coli== | |
| + | <StructureSection load='4rz4' size='340' side='right'caption='[[4rz4]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4rz4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RZ4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rz4 OCA], [https://pdbe.org/4rz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rz4 RCSB], [https://www.ebi.ac.uk/pdbsum/4rz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rz4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Aldolase 3D structures|Aldolase 3D structures]] | |
| - | + | *[[Transaldolase 3D structures|Transaldolase 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Leptihn | + | <references/> |
| - | [[Category: Samland | + | __TOC__ |
| - | [[Category: Sandalova | + | </StructureSection> |
| - | [[Category: Schneider | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: Sprenger | + | [[Category: Large Structures]] |
| - | [[Category: Stellmacher | + | [[Category: Leptihn S]] |
| + | [[Category: Samland AK]] | ||
| + | [[Category: Sandalova T]] | ||
| + | [[Category: Schneider G]] | ||
| + | [[Category: Sprenger GA]] | ||
| + | [[Category: Stellmacher L]] | ||
Current revision
Fructose-6-phosphate aldolase Q59E Y131F from E.coli
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