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4pxq

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Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide

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Retrieved from "http://52.214.119.220/wiki/index.php/4pxq"

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 ==Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide==
-<StructureSection load='4pxq' size='340' side='right' caption='[[4pxq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='4pxq' size='340' side='right'caption='[[4pxq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4pxq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PXQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4pxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PXQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pw2|4pw2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heparosan-N-sulfate-glucuronate_5-epimerase Heparosan-N-sulfate-glucuronate 5-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.17 5.1.3.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxq OCA], [https://pdbe.org/4pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pxq RCSB], [https://www.ebi.ac.uk/pdbsum/4pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pxq ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pxq RCSB], [http://www.ebi.ac.uk/pdbsum/4pxq PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLCEB_DANRE GLCEB_DANRE] Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).<ref>PMID:16156897</ref> <ref>PMID:25568314</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Heparosan-N-sulfate-glucuronate 5-epimerase]]
+[[Category: Danio rerio]]
-[[Category: Brunzelle, J S]]
+[[Category: Large Structures]]
-[[Category: Ding, K]]
+[[Category: Brunzelle JS]]
-[[Category: Gu, X]]
+[[Category: Ding K]]
-[[Category: Ke, J]]
+[[Category: Gu X]]
-[[Category: Qin, Y]]
+[[Category: Ke J]]
-[[Category: Tan, J]]
+[[Category: Qin Y]]
-[[Category: Xu, H E]]
+[[Category: Tan J]]
-[[Category: Epimerization enzyme]]
+[[Category: Xu HE]]
-[[Category: Heparan sulfate]]
-[[Category: Heparan sulfate c5-epimerase]]
-[[Category: Heparin]]
-[[Category: Isomerase]]
-[[Category: Multiple domain structure]]

4pxq

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Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide

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