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2cl3

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==CRYSTAL STRUCTURE OF HUMAN CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 5 (CPSF5)==
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<StructureSection load='2cl3' size='340' side='right' caption='[[2cl3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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==Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5)==
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<StructureSection load='2cl3' size='340' side='right'caption='[[2cl3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cl3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CL3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cl3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CL3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2cl3 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cl3 OCA], [https://pdbe.org/2cl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cl3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cl3 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cl3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cl3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cl3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den]]
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[[Category: Arrowsmith C]]
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[[Category: Berglund, H]]
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[[Category: Berglund H]]
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[[Category: Collins, R]]
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[[Category: Collins R]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Ehn, M]]
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[[Category: Ehn M]]
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[[Category: Flodin, S]]
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[[Category: Flodin S]]
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[[Category: Flores, A]]
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[[Category: Flores A]]
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[[Category: Graslund, S]]
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[[Category: Graslund S]]
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[[Category: Hallberg, B M]]
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[[Category: Hallberg BM]]
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[[Category: Hammarstrom, M]]
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[[Category: Hammarstrom M]]
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[[Category: Hogbom, M]]
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[[Category: Hogbom M]]
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[[Category: Kotenyova, T]]
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[[Category: Holmberg Schiavone L]]
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[[Category: Magnusdottir, A]]
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[[Category: Kotenyova T]]
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[[Category: Nilsson-Ehle, P]]
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[[Category: Magnusdottir A]]
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[[Category: Nordlund, P]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nyman, T]]
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[[Category: Nordlund P]]
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[[Category: Ogg, D]]
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[[Category: Nyman T]]
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[[Category: Persson, C]]
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[[Category: Ogg D]]
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[[Category: Sagemark, J]]
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[[Category: Persson C]]
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[[Category: Schiavone, L Holmberg]]
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[[Category: Sagemark J]]
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[[Category: Stenmark, P]]
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[[Category: Stenmark P]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Thorsell, A G]]
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[[Category: Thorsell AG]]
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[[Category: Wallden, K]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J]]
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[[Category: Wallden K]]
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[[Category: Cfim25]]
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[[Category: Weigelt J]]
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[[Category: Cpsf5]]
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[[Category: Mrna]]
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[[Category: Mrna processing]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Precursor mrna cleavage factor im]]
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[[Category: Rna-binding]]
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Current revision

Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5)

PDB ID 2cl3

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