2jh8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:14, 6 March 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jh8.gif|left|200px]]
 
-
{{Structure
+
==The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line==
-
|PDB= 2jh8 |SIZE=350|CAPTION= <scene name='initialview01'>2jh8</scene>, resolution 3.22&Aring;
+
<StructureSection load='2jh8' size='340' side='right'caption='[[2jh8]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Gun+Binding+Site+For+Chain+A'>AC1</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE'>M7G</scene> and <scene name='pdbligand=GUN:GUANINE'>GUN</scene>
+
<table><tr><td colspan='2'>[[2jh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bluetongue_virus_(serotype_10_/_American_isolate) Bluetongue virus (serotype 10 / American isolate)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JH8 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jh8 OCA], [https://pdbe.org/2jh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jh8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jh8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q65751_BTV1X Q65751_BTV1X] The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.[ARBA:ARBA00002541]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jh8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jh8 ConSurf].
 +
<div style="clear:both"></div>
-
'''THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE'''
+
==See Also==
-
 
+
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
+
[[Category: Large Structures]]
-
 
+
[[Category: Grimes JM]]
-
==About this Structure==
+
[[Category: Roy P]]
-
2JH8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bluetongue_virus_10_(isolate_usa) Bluetongue virus 10 (isolate usa)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JH8 OCA].
+
[[Category: Stuart DI]]
-
 
+
[[Category: Sutton G]]
-
==Reference==
+
-
Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17417654 17417654]
+
-
[[Category: Bluetongue virus 10 (isolate usa)]]
+
-
[[Category: Single protein]]
+
-
[[Category: Grimes, J M.]]
+
-
[[Category: Roy, P.]]
+
-
[[Category: Stuart, D I.]]
+
-
[[Category: Sutton, G.]]
+
-
[[Category: GUN]]
+
-
[[Category: M7G]]
+
-
[[Category: core protein]]
+
-
[[Category: guanylyltransferase]]
+
-
[[Category: methyltransferase]]
+
-
[[Category: viral capping enzyme]]
+
-
[[Category: viral protein]]
+
-
[[Category: virion protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:53 2008''
+

Current revision

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

PDB ID 2jh8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jh8"
Personal tools