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2c0d

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==STRUCTURE OF THE MITOCHONDRIAL 2-CYS PEROXIREDOXIN FROM PLASMODIUM FALCIPARUM==
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<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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==Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum==
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<StructureSection load='2c0d' size='340' side='right'caption='[[2c0d]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [https://pdbe.org/2c0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [https://www.ebi.ac.uk/pdbsum/2c0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0d ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8I5Q6_PLAF7 Q8I5Q6_PLAF7] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.[PIRNR:PIRNR000239]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0d_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0d ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2c0d" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Peroxiredoxin|Peroxiredoxin]]
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Peroxidase]]
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Boucher, I W]]
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[[Category: Boucher IW]]
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[[Category: Brannigan, J A]]
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[[Category: Brannigan JA]]
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[[Category: Brzozowski, A M]]
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[[Category: Brzozowski AM]]
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[[Category: Muller, S]]
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[[Category: Muller S]]
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[[Category: Wilkinson, A J]]
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[[Category: Wilkinson AJ]]
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[[Category: 2-cy]]
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[[Category: Antioxidant]]
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[[Category: Mitochondrial]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxiredoxin]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin dependant]]
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Current revision

Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum

PDB ID 2c0d

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