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2ch0
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2ch0' size='340' side='right' caption='[[2ch0 | + | ==Solution structure of the human MAN1 C-terminal domain (residues 655- 775)== |
| + | <StructureSection load='2ch0' size='340' side='right'caption='[[2ch0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ch0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ch0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch0 OCA], [https://pdbe.org/2ch0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN] Isolated osteopoikilosis;Buschke-Ollendorff syndrome;12q14 microdeletion syndrome;Melorheostosis with osteopoikilosis. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN] Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.<ref>PMID:15601644</ref> <ref>PMID:15647271</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch0_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch0_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ch0 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ch0" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Braud | + | [[Category: Large Structures]] |
| - | [[Category: Caputo | + | [[Category: Braud S]] |
| - | [[Category: Couprie | + | [[Category: Caputo S]] |
| - | [[Category: Duband-Goulet | + | [[Category: Couprie J]] |
| - | [[Category: Gilquin | + | [[Category: Duband-Goulet I]] |
| - | [[Category: Gondry | + | [[Category: Gilquin B]] |
| - | [[Category: Lin | + | [[Category: Gondry M]] |
| - | [[Category: Worman | + | [[Category: Lin F]] |
| - | [[Category: Zinn-Justin | + | [[Category: Worman HJ]] |
| - | + | [[Category: Zinn-Justin S]] | |
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Current revision
Solution structure of the human MAN1 C-terminal domain (residues 655- 775)
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Categories: Homo sapiens | Large Structures | Braud S | Caputo S | Couprie J | Duband-Goulet I | Gilquin B | Gondry M | Lin F | Worman HJ | Zinn-Justin S
