2ha8
From Proteopedia
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==Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1== | ==Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1== | ||
| - | <StructureSection load='2ha8' size='340' side='right' caption='[[2ha8]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='2ha8' size='340' side='right'caption='[[2ha8]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ha8]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ha8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HA8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ha8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ha8 OCA], [https://pdbe.org/2ha8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ha8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ha8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ha8 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TARB1_HUMAN TARB1_HUMAN] Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.<ref>PMID:7638159</ref> <ref>PMID:8626763</ref> <ref>PMID:8846792</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2ha8_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2ha8_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ha8 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Battaile | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Battaile K]] |
| - | [[Category: Edwards | + | [[Category: Bochkarev A]] |
| - | [[Category: Loppnau | + | [[Category: Edwards AM]] |
| - | [[Category: Min | + | [[Category: Loppnau P]] |
| - | [[Category: Plotnikov | + | [[Category: Min J]] |
| - | + | [[Category: Plotnikov AN]] | |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Wu | + | [[Category: Wu H]] |
| - | [[Category: Zeng | + | [[Category: Zeng H]] |
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Current revision
Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Battaile K | Bochkarev A | Edwards AM | Loppnau P | Min J | Plotnikov AN | Sundstrom M | Weigelt J | Wu H | Zeng H
