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2gc8

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==Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase==
==Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase==
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<StructureSection load='2gc8' size='340' side='right' caption='[[2gc8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='2gc8' size='340' side='right'caption='[[2gc8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GC8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GC8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=885:1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE'>885</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=885:1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE'>885</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gc8 RCSB], [http://www.ebi.ac.uk/pdbsum/2gc8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gc8 OCA], [https://pdbe.org/2gc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gc8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q99AU2_9HEPC Q99AU2_9HEPC]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/2gc8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/2gc8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gc8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2gc8" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepatitis c virus]]
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[[Category: Hepacivirus C]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Agarwal, A]]
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[[Category: Agarwal A]]
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[[Category: Bard, J]]
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[[Category: Bard J]]
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[[Category: Chopra, R]]
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[[Category: Chopra R]]
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[[Category: Ciszewski, G]]
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[[Category: Ciszewski G]]
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[[Category: Curran, K J]]
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[[Category: Curran KJ]]
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[[Category: Ellingboe, J W]]
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[[Category: Ellingboe JW]]
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[[Category: Feld, B]]
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[[Category: Feld B]]
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[[Category: Gopalsamy, A]]
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[[Category: Gopalsamy A]]
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[[Category: Howe, A Y]]
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[[Category: Howe AY]]
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[[Category: Krishnamurthy, G]]
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[[Category: Krishnamurthy G]]
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[[Category: Lim, K]]
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[[Category: Lim K]]
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[[Category: Mansour, T S]]
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[[Category: Mansour TS]]
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[[Category: Orlowski, M]]
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[[Category: O'connell J]]
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[[Category: Shi, M]]
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[[Category: Orlowski M]]
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[[Category: Sukits, S F]]
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[[Category: Shi M]]
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[[Category: Svenson, K]]
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[[Category: Sukits SF]]
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[[Category: Connell, J O]]
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[[Category: Svenson K]]
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[[Category: Transferase]]
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Current revision

Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

PDB ID 2gc8

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