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2vxs

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==STRUCTURE OF IL-17A IN COMPLEX WITH A POTENT, FULLY HUMAN NEUTRALISING ANTIBODY==
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<StructureSection load='2vxs' size='340' side='right' caption='[[2vxs]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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==Structure of IL-17A in complex with a potent, fully human neutralising antibody==
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<StructureSection load='2vxs' size='340' side='right'caption='[[2vxs]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vxs]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vxs]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxs RCSB], [http://www.ebi.ac.uk/pdbsum/2vxs PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxs OCA], [https://pdbe.org/2vxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxs RCSB], [https://www.ebi.ac.uk/pdbsum/2vxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxs ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxs_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxs_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vxs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vxs" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Abbott, W M]]
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[[Category: Large Structures]]
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[[Category: Aziz, A]]
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[[Category: Abbott WM]]
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[[Category: Barker, W]]
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[[Category: Aziz A]]
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[[Category: Bell, P]]
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[[Category: Barker W]]
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[[Category: Coales, S J]]
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[[Category: Bell P]]
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[[Category: Davies, R A]]
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[[Category: Coales SJ]]
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[[Category: Dawson, S]]
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[[Category: Davies RA]]
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[[Category: Gerhardt, S]]
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[[Category: Dawson S]]
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[[Category: Hamuro, Y]]
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[[Category: Gerhardt S]]
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[[Category: Hargreaves, D]]
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[[Category: Hamuro Y]]
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[[Category: Langham, C]]
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[[Category: Hargreaves D]]
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[[Category: Needham, M R.C]]
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[[Category: Langham C]]
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[[Category: Pauptit, R A]]
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[[Category: Needham MRC]]
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[[Category: Russell, C]]
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[[Category: Pauptit RA]]
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[[Category: Smith, M J]]
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[[Category: Russell C]]
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[[Category: Tuske, S J]]
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[[Category: Smith MJ]]
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[[Category: Welsh, F]]
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[[Category: Tuske SJ]]
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[[Category: Antibody]]
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[[Category: Welsh F]]
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[[Category: Complex]]
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[[Category: Cytokine]]
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[[Category: Epitope]]
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[[Category: Glycoprotein]]
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[[Category: Interleukin-17]]
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[[Category: Secreted]]
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Current revision

Structure of IL-17A in complex with a potent, fully human neutralising antibody

PDB ID 2vxs

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