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2vz6

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==STRUCTURE OF HUMAN CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA (CAMK2A) IN COMPLEX WITH INDIRUBIN E804==
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<StructureSection load='2vz6' size='340' side='right' caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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==Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804==
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<StructureSection load='2vz6' size='340' side='right'caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vz6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [https://pdbe.org/2vz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz6 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCC2A_HUMAN KCC2A_HUMAN] CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vz6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vz6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vz6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vz6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Calcium/Calmodulin-dependent protein kinase|Calcium/Calmodulin-dependent protein kinase]]
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Burgess-Brown, N]]
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[[Category: Bountra C]]
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[[Category: Delft, F Von]]
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[[Category: Burgess-Brown N]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Fedorov, O]]
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[[Category: Fedorov O]]
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[[Category: King, O]]
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[[Category: King O]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Murray, J W]]
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[[Category: Murray JW]]
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[[Category: Parizotto, E]]
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[[Category: Parizotto E]]
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[[Category: Pike, A C.W]]
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[[Category: Pike ACW]]
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[[Category: Rellos, P]]
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[[Category: Rellos P]]
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[[Category: Roos, A]]
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[[Category: Roos A]]
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[[Category: Salah, E]]
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[[Category: Salah E]]
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[[Category: Shrestha, L]]
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[[Category: Shrestha L]]
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[[Category: Wikstroem, M]]
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[[Category: Wikstroem M]]
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[[Category: Atp-binding]]
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[[Category: Von Delft F]]
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[[Category: Brain]]
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[[Category: Calmodulin-binding]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Kinase]]
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[[Category: Long term potentiation]]
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[[Category: Membrane]]
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[[Category: Nmda receptor signalling]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Synapse]]
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[[Category: Transferase]]
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Current revision

Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804

PDB ID 2vz6

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