2vr3

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==STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF FIBRINOGEN BINDING TO CLFA FROM STAPHYLOCCCUS AUREUS==
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<StructureSection load='2vr3' size='340' side='right' caption='[[2vr3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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==Structural and Biochemical Characterization of Fibrinogen binding to ClfA from Staphylocccus aureus==
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<StructureSection load='2vr3' size='340' side='right'caption='[[2vr3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vr3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VR3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vr3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fzb|1fzb]], [[1rf1|1rf1]], [[1lt9|1lt9]], [[1fid|1fid]], [[1fzc|1fzc]], [[1n8e|1n8e]], [[1re4|1re4]], [[1n86|1n86]], [[1fza|1fza]], [[1dug|1dug]], [[1re3|1re3]], [[1ltj|1ltj]], [[1fzg|1fzg]], [[1fzf|1fzf]], [[2fib|2fib]], [[2ffd|2ffd]], [[1fze|1fze]], [[1rf0|1rf0]], [[1fic|1fic]], [[1fib|1fib]], [[3fib|3fib]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vr3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr3 OCA], [https://pdbe.org/2vr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr3 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:[http://omim.org/entry/202400 202400]]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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[https://www.uniprot.org/uniprot/CLFA_STAA8 CLFA_STAA8] Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.<ref>PMID:10225887</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vr3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vr3" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Bowden, M G]]
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[[Category: Bowden MG]]
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[[Category: Fitzgerald, J R]]
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[[Category: Fitzgerald JR]]
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[[Category: Ganesh, V K]]
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[[Category: Ganesh VK]]
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[[Category: Gurusidappa, S]]
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[[Category: Gurusidappa S]]
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[[Category: Hook, M]]
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[[Category: Hook M]]
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[[Category: Rivera, J J]]
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[[Category: Rivera JJ]]
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[[Category: Smeds, E]]
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[[Category: Smeds E]]
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[[Category: Wann, E R]]
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[[Category: Wann ER]]
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[[Category: Cell adhesion]]
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[[Category: Cell wall]]
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[[Category: Clumping factor]]
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[[Category: Fibrinogen gamma-chain]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Platelet aggregation]]
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[[Category: Secreted]]
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[[Category: Virulence]]
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Current revision

Structural and Biochemical Characterization of Fibrinogen binding to ClfA from Staphylocccus aureus

PDB ID 2vr3

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