2w3l
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2w3l' size='340' side='right' caption='[[2w3l]], [[Resolution|resolution]] 2.10Å' scene=''> | + | ==Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex== |
| + | <StructureSection load='2w3l' size='340' side='right'caption='[[2w3l]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w3l]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2w3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3L FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRO:1-(2-{[(3S)-3-(AMINOMETHYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}PHENYL)-4-CHLORO-5-METHYL-N,N-DIPHENYL-1H-PYRAZOLE-3-CARBOXAMIDE'>DRO</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DRO:1-(2-{[(3S)-3-(AMINOMETHYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}PHENYL)-4-CHLORO-5-METHYL-N,N-DIPHENYL-1H-PYRAZOLE-3-CARBOXAMIDE'>DRO</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3l OCA], [https://pdbe.org/2w3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3l RCSB], [https://www.ebi.ac.uk/pdbsum/2w3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3l ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3l_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3l_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w3l ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2w3l" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Davis | + | [[Category: Davis J]] |
| - | [[Category: Edwards | + | [[Category: Edwards C]] |
| - | [[Category: Fisher | + | [[Category: Fisher M]] |
| - | [[Category: Ford | + | [[Category: Ford D]] |
| - | [[Category: Hutchinson | + | [[Category: Hutchinson B]] |
| - | [[Category: Lamers | + | [[Category: Lamers M]] |
| - | [[Category: Payne | + | [[Category: Payne A]] |
| - | [[Category: Porter | + | [[Category: Porter J]] |
| - | [[Category: Stubberfield | + | [[Category: Stubberfield C]] |
| - | [[Category: Trevitt | + | [[Category: Trevitt G]] |
| - | [[Category: Turner | + | [[Category: Turner J]] |
| - | [[Category: Watkins | + | [[Category: Watkins C]] |
| - | [[Category: Whitcombe | + | [[Category: Whitcombe I]] |
| - | [[Category: | + | [[Category: De Candole B]] |
Current revision
Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex
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Categories: Homo sapiens | Large Structures | Davis J | Edwards C | Fisher M | Ford D | Hutchinson B | Lamers M | Payne A | Porter J | Stubberfield C | Trevitt G | Turner J | Watkins C | Whitcombe I | De Candole B
