This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2m3i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:27, 14 June 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors==
==Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors==
-
<StructureSection load='2m3i' size='340' side='right' caption='[[2m3i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2m3i' size='340' side='right'caption='[[2m3i]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2m3i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M3I FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2m3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_lividus Conus lividus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3I FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m3i RCSB], [http://www.ebi.ac.uk/pdbsum/2m3i PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3i OCA], [https://pdbe.org/2m3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3i RCSB], [https://www.ebi.ac.uk/pdbsum/2m3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3i ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CA1C_CONLI CA1C_CONLI] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits alpha-3-beta-4, alpha-6/alpha-3-beta-4, and alpha-2-beta-4 nAChRs.[UniProtKB:K8DWB5]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 14: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2m3i" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Akcan, M]]
+
[[Category: Conus lividus]]
-
[[Category: Christensen, S]]
+
[[Category: Large Structures]]
-
[[Category: Craik, D J]]
+
[[Category: Akcan M]]
-
[[Category: Hu, Y]]
+
[[Category: Christensen S]]
-
[[Category: Luo, S]]
+
[[Category: Craik DJ]]
-
[[Category: McIntosh, J M]]
+
[[Category: Hu Y]]
-
[[Category: Wu, Y]]
+
[[Category: Luo S]]
-
[[Category: Zhangsun, D]]
+
[[Category: McIntosh JM]]
-
[[Category: Zhu, X]]
+
[[Category: Wu Y]]
-
[[Category: Alpha-conotoxin]]
+
[[Category: Zhangsun D]]
-
[[Category: Alpha-helix]]
+
[[Category: Zhu X]]
-
[[Category: Amidated c-terminus]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Toxin]]
+

Current revision

Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors

PDB ID 2m3i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m3i"
Personal tools