2m3i

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==Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors==
==Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors==
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<StructureSection load='2m3i' size='340' side='right' caption='[[2m3i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2m3i' size='340' side='right'caption='[[2m3i]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m3i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_lividus Conus lividus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3I FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m3i RCSB], [http://www.ebi.ac.uk/pdbsum/2m3i PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3i OCA], [https://pdbe.org/2m3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3i RCSB], [https://www.ebi.ac.uk/pdbsum/2m3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3i ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CA112_CONLI CA112_CONLI] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits alpha-3-beta-4, alpha-6/alpha-3-beta-4, and alpha-2-beta-4 nAChRs.[UniProtKB:K8DWB5]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2m3i" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Akcan, M]]
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[[Category: Conus lividus]]
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[[Category: Christensen, S]]
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[[Category: Large Structures]]
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[[Category: Craik, D J]]
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[[Category: Akcan M]]
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[[Category: Hu, Y]]
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[[Category: Christensen S]]
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[[Category: Luo, S]]
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[[Category: Craik DJ]]
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[[Category: McIntosh, J M]]
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[[Category: Hu Y]]
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[[Category: Wu, Y]]
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[[Category: Luo S]]
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[[Category: Zhangsun, D]]
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[[Category: McIntosh JM]]
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[[Category: Zhu, X]]
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[[Category: Wu Y]]
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[[Category: Alpha-conotoxin]]
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[[Category: Zhangsun D]]
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[[Category: Alpha-helix]]
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[[Category: Zhu X]]
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[[Category: Amidated c-terminus]]
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[[Category: Disulfide bond]]
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[[Category: Toxin]]
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Current revision

Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors

PDB ID 2m3i

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