2w5e

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==STRUCTURAL AND BIOCHEMICAL ANALYSIS OF HUMAN PATHOGENIC ASTROVIRUS SERINE PROTEASE AT 2.0 ANGSTROM RESOLUTION==
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<StructureSection load='2w5e' size='340' side='right' caption='[[2w5e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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==Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 Angstrom resolution==
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<StructureSection load='2w5e' size='340' side='right'caption='[[2w5e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w5e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_astrovirus_1 Human astrovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w5e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_astrovirus_1 Human astrovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5e RCSB], [http://www.ebi.ac.uk/pdbsum/2w5e PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5e OCA], [https://pdbe.org/2w5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5e RCSB], [https://www.ebi.ac.uk/pdbsum/2w5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5e ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3ZN04_HASV1 Q3ZN04_HASV1] Protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.[ARBA:ARBA00029406]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5e_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5e_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w5e ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2w5e" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human astrovirus 1]]
[[Category: Human astrovirus 1]]
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[[Category: Barthel, J]]
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[[Category: Large Structures]]
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[[Category: Bonivento, D]]
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[[Category: Barthel J]]
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[[Category: Canard, B]]
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[[Category: Bonivento D]]
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[[Category: Coutard, B]]
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[[Category: Canard B]]
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[[Category: Mattevi, A]]
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[[Category: Coutard B]]
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[[Category: Nenci, S]]
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[[Category: Mattevi A]]
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[[Category: Robel, I]]
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[[Category: Nenci S]]
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[[Category: Rohayem, J]]
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[[Category: Robel I]]
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[[Category: Speroni, S]]
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[[Category: Rohayem J]]
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[[Category: Antiviral]]
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[[Category: Speroni S]]
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[[Category: Astrovirus]]
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[[Category: Catalytic triad]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Protease]]
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[[Category: Rna replication]]
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[[Category: Serine protease]]
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[[Category: Thiol protease]]
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[[Category: Transmembrane]]
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Current revision

Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 Angstrom resolution

PDB ID 2w5e

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