2uz3

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==CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM==
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<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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==Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum==
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<StructureSection load='2uz3' size='340' side='right'caption='[[2uz3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xmr|1xmr]], [[2b8t|2b8t]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [https://pdbe.org/2uz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [https://www.ebi.ac.uk/pdbsum/2uz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KITH_UREPA KITH_UREPA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uz3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2uz3" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Thymidine kinase|Thymidine kinase]]
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thymidine kinase]]
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[[Category: Large Structures]]
[[Category: Ureaplasma urealyticum]]
[[Category: Ureaplasma urealyticum]]
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[[Category: Carnrot, C]]
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[[Category: Carnrot C]]
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[[Category: Eklund, H]]
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[[Category: Eklund H]]
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[[Category: Eriksson, S]]
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[[Category: Eriksson S]]
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[[Category: Kosinska, U]]
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[[Category: Kosinska U]]
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[[Category: Mikkelsen, N E]]
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[[Category: Mikkelsen NE]]
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[[Category: Munch-Petersen, B]]
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[[Category: Munch-Petersen B]]
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[[Category: Wang, L]]
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[[Category: Wang L]]
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[[Category: Welin, M]]
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[[Category: Welin M]]
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[[Category: Zhu, C]]
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[[Category: Zhu C]]
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[[Category: Atp-binding]]
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[[Category: Deoxyribonucleoside kinase]]
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[[Category: Dna synthesis]]
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[[Category: Dttp]]
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[[Category: Feed-back inhibitor]]
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[[Category: Kinase]]
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[[Category: Lasso-domain]]
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[[Category: Nucleotide-binding]]
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[[Category: Tk1]]
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[[Category: Transferase]]
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[[Category: Uu-tk]]
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[[Category: Zinc-binding domain]]
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Current revision

Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum

PDB ID 2uz3

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