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2qk4

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==Human glycinamide ribonucleotide synthetase==
==Human glycinamide ribonucleotide synthetase==
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<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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<StructureSection load='2qk4' size='340' side='right'caption='[[2qk4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [https://pdbe.org/2qk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qk4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PUR2_HUMAN PUR2_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qk4_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qk4_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qk4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2qk4" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoribosylamine--glycine ligase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S van den]]
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[[Category: Berglund H]]
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[[Category: Berglund, H]]
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[[Category: Busam R]]
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[[Category: Busam, R]]
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[[Category: Collins R]]
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[[Category: Collins, R]]
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[[Category: Dahlgren LG]]
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[[Category: Dahlgren, L G]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Flodin S]]
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[[Category: Flodin, S]]
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[[Category: Flores A]]
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[[Category: Flores, A]]
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[[Category: Graslund S]]
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[[Category: Graslund, S]]
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[[Category: Hallberg BM]]
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[[Category: Hallberg, B M]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M]]
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[[Category: Herman MD]]
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[[Category: Herman, M D]]
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[[Category: Holmberg-Schiavone L]]
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[[Category: Holmberg-Schiavone, L]]
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[[Category: Johansson I]]
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[[Category: Johansson, I]]
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[[Category: Kallas A]]
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[[Category: Kallas, A]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T]]
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[[Category: Lehtio L]]
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[[Category: Lehtio, L]]
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[[Category: Moche M]]
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[[Category: Moche, M]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P]]
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[[Category: Nyman T]]
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[[Category: Nyman, T]]
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[[Category: Persson C]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Structural genomic]]
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[[Category: Stenmark P]]
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[[Category: Sagemark, J]]
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[[Category: Sundstrom M]]
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[[Category: Stenmark, P]]
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[[Category: Thorsell AG]]
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[[Category: Sundstrom, M]]
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[[Category: Tresaugues L]]
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[[Category: Thorsell, A G]]
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[[Category: Weigelt J]]
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[[Category: Tresaugues, L]]
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[[Category: Welin M]]
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[[Category: Weigelt, J]]
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[[Category: Van den Berg S]]
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[[Category: Welin, M]]
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[[Category: Enzyme]]
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[[Category: Ligase]]
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[[Category: Protein-atp complex]]
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[[Category: Purine synthesis]]
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[[Category: Sgc]]
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Current revision

Human glycinamide ribonucleotide synthetase

PDB ID 2qk4

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