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2j8z

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==CRYSTAL STRUCTURE OF HUMAN P53 INDUCIBLE OXIDOREDUCTASE (TP53I3,PIG3)==
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<StructureSection load='2j8z' size='340' side='right' caption='[[2j8z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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==Crystal Structure of human P53 inducible oxidoreductase (TP53I3,PIG3)==
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<StructureSection load='2j8z' size='340' side='right'caption='[[2j8z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j8z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2j8z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oby|2oby]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8z RCSB], [http://www.ebi.ac.uk/pdbsum/2j8z PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8z OCA], [https://pdbe.org/2j8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8z RCSB], [https://www.ebi.ac.uk/pdbsum/2j8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8z ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QORX_HUMAN QORX_HUMAN] May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).<ref>PMID:19349281</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8z_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8z_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8z ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2j8z" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Debreczeni, J]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F Von]]
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[[Category: Debreczeni J]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Fita, I]]
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[[Category: Fita I]]
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[[Category: Gileadi, O]]
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[[Category: Gileadi O]]
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[[Category: Haroniti, A]]
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[[Category: Haroniti A]]
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[[Category: Johansson, C]]
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[[Category: Johansson C]]
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[[Category: Oppermann, U]]
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[[Category: Oppermann U]]
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[[Category: Pares, J]]
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[[Category: Pares J]]
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[[Category: Pares, X]]
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[[Category: Pares X]]
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[[Category: Pike, A C.W]]
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[[Category: Pike ACW]]
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[[Category: Porte, S]]
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[[Category: Porte S]]
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[[Category: Shafqat, N]]
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[[Category: Shafqat N]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Medium-chain dehydrogenase- reductase]]
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[[Category: Von Delft F]]
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[[Category: Oxidative stress response]]
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[[Category: Oxidoreductase]]
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[[Category: Quinone oxidoreductase]]
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Current revision

Crystal Structure of human P53 inducible oxidoreductase (TP53I3,PIG3)

PDB ID 2j8z

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