2jle
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2jle' size='340' side='right' caption='[[2jle]], [[Resolution|resolution]] 2.90Å' scene=''> | + | ==Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays== |
| + | <StructureSection load='2jle' size='340' side='right'caption='[[2jle]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jle]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2jle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JLE FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I15:5-[(5-FLUORO-3-METHYL-1H-INDAZOL-4-YL)OXY]BENZENE-1,3-DICARBONITRILE'>I15</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I15:5-[(5-FLUORO-3-METHYL-1H-INDAZOL-4-YL)OXY]BENZENE-1,3-DICARBONITRILE'>I15</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jle OCA], [https://pdbe.org/2jle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jle RCSB], [https://www.ebi.ac.uk/pdbsum/2jle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jle ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q72547_9HIV1 Q72547_9HIV1] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jle_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jle_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jle ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2jle" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Reverse transcriptase|Reverse transcriptase]] | + | *[[Reverse transcriptase 3D structures|Reverse transcriptase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
| - | [[Category: Allan | + | [[Category: Large Structures]] |
| - | [[Category: Barba | + | [[Category: Allan G]] |
| - | [[Category: Burt | + | [[Category: Barba O]] |
| - | [[Category: Corbau | + | [[Category: Burt C]] |
| - | [[Category: Dupont | + | [[Category: Corbau R]] |
| - | [[Category: Irving | + | [[Category: Dupont T]] |
| - | [[Category: Jones | + | [[Category: Irving S]] |
| - | [[Category: Mowbray | + | [[Category: Jones LH]] |
| - | [[Category: Phillips | + | [[Category: Mowbray CE]] |
| - | [[Category: Swain | + | [[Category: Phillips C]] |
| - | [[Category: Webster | + | [[Category: Swain NA]] |
| - | [[Category: Westby | + | [[Category: Webster R]] |
| - | + | [[Category: Westby M]] | |
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Current revision
Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays
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Categories: Human immunodeficiency virus 1 | Large Structures | Allan G | Barba O | Burt C | Corbau R | Dupont T | Irving S | Jones LH | Mowbray CE | Phillips C | Swain NA | Webster R | Westby M
