2v14

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==KINESIN 16B PHOX-HOMOLOGY DOMAIN (KIF16B)==
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<StructureSection load='2v14' size='340' side='right' caption='[[2v14]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==Kinesin 16B Phox-homology domain (KIF16B)==
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<StructureSection load='2v14' size='340' side='right'caption='[[2v14]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V14 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V14 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v14 RCSB], [http://www.ebi.ac.uk/pdbsum/2v14 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v14 OCA], [https://pdbe.org/2v14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v14 RCSB], [https://www.ebi.ac.uk/pdbsum/2v14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v14 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KI16B_HUMAN KI16B_HUMAN] Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.<ref>PMID:15882625</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v14_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v14_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v14 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2v14" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Kinesin|Kinesin]]
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blatner, N R]]
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[[Category: Large Structures]]
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[[Category: Cho, W]]
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[[Category: Blatner NR]]
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[[Category: Hong, W]]
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[[Category: Cho W]]
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[[Category: Williams, R L]]
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[[Category: Hong W]]
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[[Category: Wilson, M I]]
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[[Category: Williams RL]]
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[[Category: Atp-binding]]
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[[Category: Wilson MI]]
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[[Category: Endosome transport]]
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[[Category: Microtubule]]
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[[Category: Motor protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphatidylinositol 3-phosphate binding]]
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[[Category: Plus-end kinesin complex]]
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[[Category: Plus-end-directed microtubule motor activity]]
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[[Category: Transport protein]]
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Current revision

Kinesin 16B Phox-homology domain (KIF16B)

PDB ID 2v14

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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