4hry

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==The structure of Arabidopsis thaliana KAI2==
==The structure of Arabidopsis thaliana KAI2==
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<StructureSection load='4hry' size='340' side='right' caption='[[4hry]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4hry' size='340' side='right'caption='[[4hry]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HRY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HRY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hrx|4hrx]], [[4hta|4hta]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AT4g37470, F6G17.120 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hry OCA], [https://pdbe.org/4hry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hry RCSB], [https://www.ebi.ac.uk/pdbsum/4hry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hry ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hry OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hry RCSB], [http://www.ebi.ac.uk/pdbsum/4hry PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q9SZU7_ARATH Q9SZU7_ARATH]] Involved in seed germination and seedling development. Essential for plant responses to karrikins, a class of butenolide compounds, structurally similar to strigolactones, released from burning vegetation that stimulate seed germination and enhance seedling photomorphogenesis. KAI2 is not required for strigolactone-mediated responses, but MAX2 is necessary for responses to karrikins and strigolactones.<ref>PMID:20864454</ref> <ref>PMID:22357928</ref> <ref>PMID:23142794</ref> <ref>PMID:23301669</ref>
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[https://www.uniprot.org/uniprot/KAI2_ARATH KAI2_ARATH] Involved in seed germination and seedling development. Essential for plant responses to karrikins, a class of butenolide compounds, structurally similar to strigolactones, released from burning vegetation that stimulate seed germination and enhance seedling photomorphogenesis. KAI2 is not required for strigolactone-mediated responses, but MAX2 is necessary for responses to karrikins and strigolactones.<ref>PMID:20864454</ref> <ref>PMID:22357928</ref> <ref>PMID:23142794</ref> <ref>PMID:23301669</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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KARRIKIN INSENSITIVE 2 (KAI2) is an alpha/beta hydrolase involved in seed germination and seedling development. It is essential for plant responses to karrikins, a class of butenolide compounds derived from burnt plant material that are structurally similar to strigolactone plant hormones. The mechanistic basis for the function of KAI2 in plant development remains unclear. We have determined the crystal structure of Arabidopsis thaliana KAI2 in space groups P2(1) 2(1) 2(1) (a = 63.57 A, b = 66.26 A, c = 78.25 A) and P2(1) (a = 50.20 A, b = 56.04 A, c = 52.43 A, beta = 116.12 degrees ) to 1.55 and 2.11 A respectively. The catalytic residues are positioned within a large hydrophobic pocket similar to that of DAD2, a protein required for strigolactone response in Petunia hybrida. KAI2 possesses a second solvent-accessible pocket, adjacent to the active site cavity, which offers the possibility of allosteric regulation. The structure of KAI2 is consistent with its designation as a serine hydrolase, as well as previous data implicating the protein in karrikin and strigolactone signalling.
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The Structure of the Karrikin-Insensitive Protein (KAI2) in Arabidopsis thaliana.,Bythell-Douglas R, Waters MT, Scaffidi A, Flematti GR, Smith SM, Bond CS PLoS One. 2013;8(1):e54758. doi: 10.1371/journal.pone.0054758. Epub 2013 Jan 18. PMID:23349965<ref>PMID:23349965</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Bond, C S]]
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[[Category: Large Structures]]
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[[Category: Bythell-Douglas, R]]
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[[Category: Bond CS]]
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[[Category: Flematti, G R]]
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[[Category: Bythell-Douglas R]]
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[[Category: Scaffidi, A]]
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[[Category: Flematti GR]]
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[[Category: Smith, S M]]
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[[Category: Scaffidi A]]
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[[Category: Waters, M T]]
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[[Category: Smith SM]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: Waters MT]]
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[[Category: Hydrolase]]
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[[Category: Signaling protein]]
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The structure of Arabidopsis thaliana KAI2

PDB ID 4hry

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