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3tc3

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==Crystal Structure of SacUVDE==
==Crystal Structure of SacUVDE==
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<StructureSection load='3tc3' size='340' side='right' caption='[[3tc3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='3tc3' size='340' side='right'caption='[[3tc3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tc3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius_dsm_639 Sulfolobus acidocaldarius dsm 639]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius_DSM_639 Sulfolobus acidocaldarius DSM 639]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uvdE, Saci_1096 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330779 Sulfolobus acidocaldarius DSM 639])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tc3 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc3 OCA], [https://pdbe.org/3tc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tc3 RCSB], [https://www.ebi.ac.uk/pdbsum/3tc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc3 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4J9T1_SULAC Q4J9T1_SULAC]
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Repairing damaged DNA is essential for an organism's survival. UV damage endonuclease (UVDE) is a DNA-repair enzyme that can recognize and incise different types of damaged DNA. We present the structure of Sulfolobus acidocaldarius UVDE on its own and in a pre-catalytic complex with UV-damaged DNA containing a 6-4 photoproduct showing a novel 'dual dinucleotide flip' mechanism for recognition of damaged dipyrimidines: the two purines opposite to the damaged pyrimidine bases are flipped into a dipurine-specific pocket, while the damaged bases are also flipped into another cleft.
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UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions.,Meulenbroek EM, Peron Cane C, Jala I, Iwai S, Moolenaar GF, Goosen N, Pannu NS Nucleic Acids Res. 2012 Dec 11. PMID:23221644<ref>PMID:23221644</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sulfolobus acidocaldarius dsm 639]]
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[[Category: Large Structures]]
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[[Category: Goosen, N]]
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[[Category: Sulfolobus acidocaldarius DSM 639]]
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[[Category: Jala, I]]
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[[Category: Goosen N]]
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[[Category: Meulenbroek, E M]]
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[[Category: Jala I]]
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[[Category: Moolenaar, G F]]
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[[Category: Meulenbroek EM]]
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[[Category: Pannu, N S]]
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[[Category: Moolenaar GF]]
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[[Category: Endonuclease]]
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[[Category: Pannu NS]]
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[[Category: Hydrolase]]
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[[Category: Tim-barrel]]
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Current revision

Crystal Structure of SacUVDE

PDB ID 3tc3

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