This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2wzm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:19, 9 May 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
==CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM==
+
 
-
<StructureSection load='2wzm' size='340' side='right' caption='[[2wzm]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
+
==Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form==
 +
<StructureSection load='2wzm' size='340' side='right'caption='[[2wzm]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2wzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2wzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA7:[(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>NA7</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wzt|2wzt]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA7:[(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>NA7</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzm OCA], [https://pdbe.org/2wzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzm RCSB], [https://www.ebi.ac.uk/pdbsum/2wzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzm ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzm RCSB], [http://www.ebi.ac.uk/pdbsum/2wzm PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Y2407_MYCS2 Y2407_MYCS2]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzm_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzm_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wzm ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 26: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2wzm" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Morphine 6-dehydrogenase]]
+
[[Category: Large Structures]]
-
[[Category: Mycobacterium smegmatis]]
+
[[Category: Mycolicibacterium smegmatis MC2 155]]
-
[[Category: Beddoe, T]]
+
[[Category: Beddoe T]]
-
[[Category: Brammananth, R]]
+
[[Category: Brammananth R]]
-
[[Category: Byres, E]]
+
[[Category: Byres E]]
-
[[Category: Coppel, R L]]
+
[[Category: Coppel RL]]
-
[[Category: Crellin, P K]]
+
[[Category: Crellin PK]]
-
[[Category: Fulton, Z]]
+
[[Category: Fulton Z]]
-
[[Category: Mcalister, A D]]
+
[[Category: Le Nours J]]
-
[[Category: Nours, J Le]]
+
[[Category: McAlister AD]]
-
[[Category: Rossjohn, J]]
+
[[Category: Rossjohn J]]
-
[[Category: Scoble, J]]
+
[[Category: Scoble J]]
-
[[Category: Troy, S]]
+
[[Category: Troy S]]
-
[[Category: Vivian, J P]]
+
[[Category: Vivian JP]]
-
[[Category: Wilce, M C.J]]
+
[[Category: Wilce MCJ]]
-
[[Category: Zaker-Tabrizi, L]]
+
[[Category: Zaker-Tabrizi L]]
-
[[Category: Oxidoreductase]]
+

Current revision

Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form

PDB ID 2wzm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wzm"
Personal tools