This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3ao4
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase== | ==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase== | ||
| - | <StructureSection load='3ao4' size='340' side='right' caption='[[3ao4]], [[Resolution|resolution]] 1.95Å' scene=''> | + | <StructureSection load='3ao4' size='340' side='right'caption='[[3ao4]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ao4]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ao4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AO4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=833:3-(1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-5-AMINE'>833</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=833:3-(1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-5-AMINE'>833</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ao4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ao4 OCA], [https://pdbe.org/3ao4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ao4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ao4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ao4 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q72498_9HIV1 Q72498_9HIV1] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chalmers DK]] |
| - | [[Category: | + | [[Category: Headey SJ]] |
| - | [[Category: | + | [[Category: Parker MW]] |
| - | [[Category: | + | [[Category: Scanlon MJ]] |
| - | [[Category: | + | [[Category: Wielens J]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
| |||||||||||
