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2opw

From Proteopedia

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[[Image:2opw.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)==
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|PDB= 2opw |SIZE=350|CAPTION= <scene name='initialview01'>2opw</scene>, resolution 1.90&Aring;
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<StructureSection load='2opw' size='340' side='right'caption='[[2opw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2opw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= PHYHD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opw OCA], [https://pdbe.org/2opw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opw RCSB], [https://www.ebi.ac.uk/pdbsum/2opw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opw ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHYD1_HUMAN PHYD1_HUMAN] Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA. Isoform 2 and isoform 3 probably lack enzyme activity.<ref>PMID:21530488</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2opw ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)'''
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2OPW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPW OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bray, J E.]]
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[[Category: Bray JE]]
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[[Category: Butler, D.]]
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[[Category: Butler D]]
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[[Category: Delft, F von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Kavanagh KL]]
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[[Category: Kavanagh, K L.]]
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[[Category: McDonough MA]]
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[[Category: McDonough, M A.]]
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[[Category: Ng SS]]
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[[Category: Ng, S S.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Schofield CJ]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Schofield, C J.]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M.]]
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[[Category: Zhang Z]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Zhang, Z.]]
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[[Category: double-stranded beta helix]]
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[[Category: oxygenase]]
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[[Category: phyhd1]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:02:56 2008''
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Current revision

Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)

PDB ID 2opw

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