This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4ch0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:45, 7 September 2022) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==RRM domain from C. elegans SUP-12==
==RRM domain from C. elegans SUP-12==
-
<StructureSection load='4ch0' size='340' side='right' caption='[[4ch0]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+
<StructureSection load='4ch0' size='340' side='right'caption='[[4ch0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4ch0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CH0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4ch0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CH0 FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ch1|4ch1]], [[4cio|4cio]]</td></tr>
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ch0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ch0 OCA], [https://pdbe.org/4ch0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ch0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ch0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ch0 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ch0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ch0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ch0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ch0 PDBsum]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[[https://www.uniprot.org/uniprot/O45189_CAEEL O45189_CAEEL]]
-
Cellular differentiation is frequently accompanied by alternative splicing, enabled by the expression of tissue-specific factors which bind to pre-mRNAs and regulate exon choice. During Caenorhabditis elegans development, muscle-specific expression of the splicing factor SUP-12, together with a member of the Fox-1 family of splicing proteins, generates a functionally distinct isoform of the fibroblast growth factor receptor EGL-15. Using a combination of NMR spectroscopy and isothermal titration calorimetry, we determined the mode of nucleic acid binding by the RNA recognition motif domain of SUP-12. The calculated structures provide the first atomic details of RNA and DNA binding by the family of proteins that include SUP-12, RBM24, RBM38/RNPC1, SEB-4 and XSeb4R. This information was further used to design strategic mutations to probe the interaction with ASD-1 and to quantitatively perturb splicing in vivo.
+
-
 
+
-
Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition.,Amrane S, Rebora K, Zniber I, Dupuy D, Mackereth CD Nat Commun. 2014 Sep 3;5:4595. doi: 10.1038/ncomms5595. PMID:25183497<ref>PMID:25183497</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Amrane, S]]
+
[[Category: Caenorhabditis elegans]]
-
[[Category: Mackereth, C D]]
+
[[Category: Large Structures]]
-
[[Category: Development]]
+
[[Category: Amrane S]]
-
[[Category: Transcription]]
+
[[Category: Mackereth CD]]

Current revision

RRM domain from C. elegans SUP-12

PDB ID 4ch0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ch0"
Personal tools