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2os3

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[[Image:2os3.jpg|left|200px]]
 
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{{Structure
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==Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes==
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|PDB= 2os3 |SIZE=350|CAPTION= <scene name='initialview01'>2os3</scene>, resolution 2.26&Aring;
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<StructureSection load='2os3' size='340' side='right'caption='[[2os3]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Co+Binding+Site+For+Residue+A+300'>AC1</scene> and <scene name='pdbsite=AC2:Bb2+Binding+Site+For+Residue+A+400'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene> and <scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>
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<table><tr><td colspan='2'>[[2os3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_M1_GAS Streptococcus pyogenes M1 GAS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS3 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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|GENE= def ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 Streptococcus pyogenes])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os3 OCA], [https://pdbe.org/2os3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os3 RCSB], [https://www.ebi.ac.uk/pdbsum/2os3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os3 ProSAT]</span></td></tr>
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</table>
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'''Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes'''
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_STRP1 DEF_STRP1] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2OS3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS3 OCA].
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Check<jmol>
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[[Category: Peptide deformylase]]
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<jmolCheckbox>
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[[Category: Single protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os3_consurf.spt"</scriptWhenChecked>
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[[Category: Streptococcus pyogenes]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Choi, K.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Kim, E E.]]
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</jmolCheckbox>
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[[Category: Kim, K H.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os3 ConSurf].
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[[Category: Lee, H K.]]
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<div style="clear:both"></div>
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[[Category: Moon, J H.]]
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__TOC__
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[[Category: Parh, H S.]]
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</StructureSection>
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[[Category: BB2]]
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[[Category: Large Structures]]
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[[Category: CO]]
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[[Category: Streptococcus pyogenes M1 GAS]]
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[[Category: hydrolase]]
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[[Category: Choi K]]
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[[Category: pdf]]
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[[Category: Kim EE]]
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[[Category: peptide deformylase]]
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[[Category: Kim K-H]]
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[[Category: Lee HK]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:03:46 2008''
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[[Category: Moon JH]]
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[[Category: Parh HS]]

Current revision

Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes

PDB ID 2os3

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