2wkk

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==Identification of the glycan target of the nematotoxic fungal galectin CGL2 in Caenorhabditis elegans==
==Identification of the glycan target of the nematotoxic fungal galectin CGL2 in Caenorhabditis elegans==
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<StructureSection load='2wkk' size='340' side='right' caption='[[2wkk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='2wkk' size='340' side='right'caption='[[2wkk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Copci Copci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wkk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WKK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ule|1ule]], [[1ulg|1ulg]], [[1ulf|1ulf]], [[1ul9|1ul9]], [[1ulc|1ulc]], [[1uld|1uld]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wkk RCSB], [http://www.ebi.ac.uk/pdbsum/2wkk PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wkk OCA], [https://pdbe.org/2wkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wkk RCSB], [https://www.ebi.ac.uk/pdbsum/2wkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wkk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI]] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>
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[https://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wkk_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wkk_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wkk ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2wkk" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Galectin|Galectin]]
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*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Copci]]
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[[Category: Coprinopsis cinerea]]
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[[Category: Aebi, M]]
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[[Category: Large Structures]]
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[[Category: Butschi, A]]
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[[Category: Aebi M]]
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[[Category: Hengartner, M O]]
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[[Category: Butschi A]]
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[[Category: Kuenzler, M]]
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[[Category: Hengartner MO]]
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[[Category: Olieric, V]]
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[[Category: Kuenzler M]]
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[[Category: Paschinger, K]]
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[[Category: Olieric V]]
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[[Category: Seeberger, P H]]
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[[Category: Paschinger K]]
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[[Category: Titz, A]]
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[[Category: Seeberger PH]]
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[[Category: Waelti, M]]
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[[Category: Titz A]]
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[[Category: Wilson, I B.H]]
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[[Category: Waelti M]]
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[[Category: Xiaoqiang, G]]
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[[Category: Wilson IBH]]
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[[Category: Beta-galactoside binding lectin]]
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[[Category: Xiaoqiang G]]
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[[Category: Cell wall]]
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[[Category: Extracellular matrix]]
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[[Category: Fruiting body]]
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[[Category: Galectin]]
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[[Category: Lectin]]
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[[Category: Secreted]]
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[[Category: Sugar binding]]
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[[Category: Sugar binding protein]]
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[[Category: Sugar-binding protein]]
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Current revision

Identification of the glycan target of the nematotoxic fungal galectin CGL2 in Caenorhabditis elegans

PDB ID 2wkk

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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