Acetyl-CoA synthetase

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{{STRUCTURE_2p2j| PDB=2p2j | SIZE=400| SCENE= |right|CAPTION=2 monomers of acetyl-CoA synthetase complex with CoA and AMP, [[2p2j]] }}
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<StructureSection load='' size='350' side='right' scene='49/492048/Cv/9' caption='Acetyl-CoA synthetase complex with CoA and AMP (PDB code [[2p2j]])'>
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<!--
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__TOC__
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== Function ==
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'''Acetyl-CoA synthetase''' (ACS) catalyzes the ligation of acetate and CoA to form acetyl-CoA with the conversion of ATP to AMP and pyrophosphate. The acetyl-CoA is used in aerobic respiration to produce energy and electron carriers and for lipid biosynthesis. ACS is an ATP-dependent AMP-binding enzyme.
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==3D structures of acetyl-CoA synthetase==
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'''Acetyl-CoA synthetase''' (ACS) catalyzes the ligation of acetate and CoA to form acetyl-CoA with the conversion of ATP to AMP and pyrophosphate. ACS is an ATP-dependent AMP-binding enzyme. Mg+2 is ACS cofactor. ACS participates in the pathway which fixes CO2 under anaerobic conditions. ACS acetylates the response regulator for flagellar movement and for chemotaxis - CheY. <ref>PMID:14769018</ref>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== Relevance ==
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Acetyl-CoA is used in aerobic respiration to produce energy and electron carriers and for lipid biosynthesis, in histone acetylation which is critical for DNA condensation to chromatin.
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== Structural Highlights ==
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*<scene name='49/492048/Cv/10'>CoA binding site</scene>. Water molecules shown as red spheres.
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*<scene name='49/492048/Cv/7'>AMP binding site</scene>.
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*<scene name='49/492048/Cv/8'>CoA/AMP binding site</scene> ([[2p2j]]).<ref>PMID:17497934</ref>
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==3D structures of acetyl-CoA synthetase==
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[[Acetyl-CoA synthetase 3D structures]]
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</StructureSection>
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[[1pg3]], [[1pg4]] – SeACS (mutant) + CoA + AMP – ''Salmonella enterica''<br />
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== References ==
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[[2p20]], [[2p2m]], [[2p2q]] - StACS (mutant) + AMP – ''Salmonella typhimurium''<br />
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<references/>
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[[2p2b]], [[2p2j]] - StACS (mutant) + CoA + AMP<br />
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[[Category:Topic Page]]
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[[2p2f]] - StACS + CoA + AMP<br />
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[[1ry2]] – ACS + AMP - yeast<br />
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[[4u5y]] – ACS GNAT domain + SeACS C terminal (mutant) – ''Streptomyces lividans''<br />
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Current revision

Acetyl-CoA synthetase complex with CoA and AMP (PDB code 2p2j)

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References

  1. ↑ Jogl G, Tong L. Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry. 2004 Feb 17;43(6):1425-31. PMID:14769018 doi:10.1021/bi035911a
  2. ↑ Reger AS, Carney JM, Gulick AM. Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry. 2007 Jun 5;46(22):6536-46. Epub 2007 May 12. PMID:17497934 doi:http://dx.doi.org/10.1021/bi6026506

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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