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2l2a

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==Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor==
==Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor==
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<StructureSection load='2l2a' size='340' side='right' caption='[[2l2a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l2a' size='340' side='right'caption='[[2l2a]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2A FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cnj|2cnj]], [[1gp0|1gp0]], [[2l21|2l21]], [[2l29|2l29]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2a OCA], [https://pdbe.org/2l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2a RCSB], [https://www.ebi.ac.uk/pdbsum/2l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2a ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">igf2r ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l2a RCSB], [http://www.ebi.ac.uk/pdbsum/2l2a PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2l2a" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Crump, M P]]
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[[Category: Large Structures]]
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[[Category: Ellis, R Z]]
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[[Category: Crump MP]]
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[[Category: Forbes, B]]
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[[Category: Ellis RZ]]
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[[Category: Frago, S]]
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[[Category: Forbes B]]
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[[Category: Hassan, A B]]
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[[Category: Frago S]]
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[[Category: Hoppe, H]]
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[[Category: Hassan AB]]
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[[Category: Jones, E Y]]
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[[Category: Hoppe H]]
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[[Category: Prince, S N]]
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[[Category: Jones EY]]
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[[Category: Rezgui, D]]
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[[Category: Prince SN]]
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[[Category: Strickland, M]]
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[[Category: Rezgui D]]
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[[Category: Wattana-Amorn, P]]
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[[Category: Strickland M]]
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[[Category: Williams, C]]
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[[Category: Wattana-Amorn P]]
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[[Category: Zaccheo, O J]]
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[[Category: Williams C]]
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[[Category: Genomic imprinting]]
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[[Category: Zaccheo OJ]]
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[[Category: Insulin-like growth factor 2]]
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[[Category: Mannose 6 phosphate receptor]]
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[[Category: Protein evolution]]
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[[Category: Transport protein]]
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Current revision

Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor

PDB ID 2l2a

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