Adenosine kinase

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<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine (stick model), Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene=''>
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<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene='57/573962/Cv/1'>
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== Function ==
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'''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. AdK deficiency causes hypermethioninemia.
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'''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.<ref>PMID:18560757</ref>
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</StructureSection>
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==3D structures of adenosine kinase==
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== Disease ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Adenosine kinase
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== Structural highlights ==
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**[[1lio]] – TgAdK – ''Toxoplasma gondii''<br />
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AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene> (PDB entry [[1bx4]]).<ref>PMID:9843365</ref>
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**[[2pkf]] – MtAdK – ''Mycobacterium tuberculosis''<br />
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*<scene name='57/573962/Cv/6'>1st adenosine binding site</scene>. Water molecules are shown as red spheres.
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**[[4n08]] – TbAdK – ''Trypanosoma brucei''<br />
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*<scene name='57/573962/Cv/7'>Cl coordination site</scene>.
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*<scene name='57/573962/Cv/8'>Cl/Mg cluster coordination site</scene>.
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*<scene name='57/573962/Cv/11'>2nd adenosine binding site</scene>.
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*Adenosine kinase binary complex
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==3D structures of adenosine kinase==
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[[Adenosine kinase 3D structures]]
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**[[1bx4]] – hAdK + adenosine - human<br />
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</StructureSection>
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**[[2i6a]], [[2i6b]] – hAdK + prodrug <br />
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**[[4o1l]] – hAdK + inhibitor <br />
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**[[1dgm]], [[1lik]] – TgAdK + adenosine <br />
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**[[2a9y]] – TgAdK (mutant) + dimethyladenosine <br />
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**[[2abs]] – TgAdK (mutant) + AMP-PCP<br />
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**[[2aa0]] – TgAdK (mutant) + methylthiopurine <br />
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**[[2pkk]], [[4ube]] – MtAdK + fluoroadenosine <br />
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**[[2pkn]] – MtAdK + AMP-PCP<br />
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**[[2pkm]] – MtAdK + adenosine <br />
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**[[4o1g]] – MtAdK + γ-thio-ATP <br />
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**[[4pvv]] – MtAdK + inhibitor <br />
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**[[3loo]] – AdK + adenosine tetraphosphate – ''Anopheles gambiae''<br />
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**[[2xtb]] – TbAdK + morpholine <br />
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*Adenosine kinase ternary complex
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**[[1lii]] – TgAdK + adenosine + AMP-PCP<br />
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== References ==
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**[[2a9z]] – TgAdK (mutant) + dimethyladenosine + AMP-PCP<br />
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<references/>
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**[[1lij]] – TgAdK + prodrug + AMP-PCP<br />
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**[[2ab8]] – TgAdK (mutant) + methylthiopurine + AMP-PCP<br />
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**[[3ubo]] – AdK + adenosine + ADP – ''Sinorhizobium meliloti''<br />
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**[[4dc3]] – AdK + adenosine + fluoroadenosine – ''Schistosoma masoni''<br />
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**[[4n09]] – TbAdK + adenosine + ADP <br />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4)

Drag the structure with the mouse to rotate

References

  1. ↑ Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1
  2. ↑ Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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