4nxi

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==Rv2466c Mediates the Activation of TP053 To Kill Replicating and Non-replicating Mycobacterium tuberculosis==
==Rv2466c Mediates the Activation of TP053 To Kill Replicating and Non-replicating Mycobacterium tuberculosis==
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<StructureSection load='4nxi' size='340' side='right' caption='[[4nxi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4nxi' size='340' side='right'caption='[[4nxi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nxi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NXI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nxi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NXI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.698&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nxi RCSB], [http://www.ebi.ac.uk/pdbsum/4nxi PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxi OCA], [https://pdbe.org/4nxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nxi RCSB], [https://www.ebi.ac.uk/pdbsum/4nxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nxi ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRLR_MYCTU TRLR_MYCTU] In vitro, the reduced form of Rv2466c catalyzes the reduction and activation of TP053, which is a thienopyrimidine derivative drug that can kill both replicating and non-replicating M.tuberculosis.<ref>PMID:24877756</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4nxi" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Albesa-Jove, D]]
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[[Category: Large Structures]]
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[[Category: Comino, N]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Guerin, M E]]
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[[Category: Albesa-Jove D]]
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[[Category: Urresti, S]]
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[[Category: Comino N]]
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[[Category: Oxidoreductase]]
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[[Category: Guerin ME]]
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[[Category: Thioredoxin]]
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[[Category: Urresti S]]

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Rv2466c Mediates the Activation of TP053 To Kill Replicating and Non-replicating Mycobacterium tuberculosis

PDB ID 4nxi

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