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4edi

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==Disulfide bonded EutL from Clostridium perfringens==
==Disulfide bonded EutL from Clostridium perfringens==
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<StructureSection load='4edi' size='340' side='right' caption='[[4edi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4edi' size='340' side='right'caption='[[4edi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4edi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EDI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4edi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPE0900, eutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 Clostridium perfringens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4edi RCSB], [http://www.ebi.ac.uk/pdbsum/4edi PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edi OCA], [https://pdbe.org/4edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4edi RCSB], [https://www.ebi.ac.uk/pdbsum/4edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4edi ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EUTL_CLOPE EUTL_CLOPE] A component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation. May be involved in cofactor diffusion across the BMC (Probable). Cobalamin is covalently bound to 1 subunit of the trimer on the concave (lumenal) face in a closed pore conformation; whether this is physiologically relevant is unclear (PubMed:25484204). The closed form has 3 very narrow channels (1.3 Angstrom at their narrowest) per trimer lined by acidic and aromatic residues; 2 ethanolamine molecules can bind in each channel, on either side of the constriction. Does not bind acetate, ethanol or acetyl phosphate, all of which are small molecules involved in ethanolamine metabolism (PubMed:25752492). Ethanolamine-binding has been hypothesized to stabilize the EutL central pore in a closed (non-transporting) state. An open pore is thought to be large enough to transport ATP and/or cobalamin (Probable).<ref>PMID:25484204</ref> <ref>PMID:25752492</ref> <ref>PMID:25484204</ref> <ref>PMID:25752492</ref> <ref>PMID:29717712</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
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[[Category: Cascio, D]]
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[[Category: Large Structures]]
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[[Category: Crowley, C S]]
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[[Category: Cascio D]]
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[[Category: Kopstein, J S]]
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[[Category: Crowley CS]]
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[[Category: Thompson, M C]]
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[[Category: Kopstein JS]]
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[[Category: Yeates, T O]]
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[[Category: Thompson MC]]
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[[Category: Bacterial microcompartment]]
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[[Category: Yeates TO]]
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[[Category: Bmc shell protein]]
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[[Category: Eut]]
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[[Category: Transport protein]]
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Current revision

Disulfide bonded EutL from Clostridium perfringens

PDB ID 4edi

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