4s1f
From Proteopedia
(Difference between revisions)
(3 intermediate revisions not shown.) | |||
Line 1: | Line 1: | ||
- | '''Unreleased structure''' | ||
- | + | ==Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone== | |
+ | <StructureSection load='4s1f' size='340' side='right'caption='[[4s1f]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[4s1f]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1F FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.242Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P2D:PENTANE-2,4-DIONE'>P2D</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1f OCA], [https://pdbe.org/4s1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1f RCSB], [https://www.ebi.ac.uk/pdbsum/4s1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1f ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref> | ||
- | + | ==See Also== | |
- | + | *[[Aldolase 3D structures|Aldolase 3D structures]] | |
- | + | *[[Transaldolase 3D structures|Transaldolase 3D structures]] | |
- | [[Category: | + | == References == |
- | [[Category: Leptihn | + | <references/> |
- | [[Category: Samland | + | __TOC__ |
- | [[Category: Sandalova | + | </StructureSection> |
- | [[Category: Schneider | + | [[Category: Escherichia coli K-12]] |
- | [[Category: Sprenger | + | [[Category: Large Structures]] |
- | [[Category: Stellmacher | + | [[Category: Leptihn S]] |
+ | [[Category: Samland AK]] | ||
+ | [[Category: Sandalova T]] | ||
+ | [[Category: Schneider G]] | ||
+ | [[Category: Sprenger GA]] | ||
+ | [[Category: Stellmacher L]] |
Current revision
Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone
|