This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4fgt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:48, 19 October 2022) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.==
==Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.==
-
<StructureSection load='4fgt' size='340' side='right' caption='[[4fgt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='4fgt' size='340' side='right'caption='[[4fgt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4fgt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FGT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4fgt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FGT FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgt OCA], [https://pdbe.org/4fgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fgt RCSB], [https://www.ebi.ac.uk/pdbsum/4fgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgt ProSAT]</span></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n5e|3n5e]], [[3egy|3egy]]</td></tr>
+
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYMS, TS, OK/SW-cl.29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fgt RCSB], [http://www.ebi.ac.uk/pdbsum/4fgt PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
+
[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4fgt" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Thymidylate synthase|Thymidylate synthase]]
+
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Thymidylate synthase]]
+
[[Category: Large Structures]]
-
[[Category: Costi, M P]]
+
[[Category: Synthetic construct]]
-
[[Category: Finer-Moore, J]]
+
[[Category: Costi MP]]
-
[[Category: Stroud, R M]]
+
[[Category: Finer-Moore J]]
-
[[Category: Tochowicz, A]]
+
[[Category: Stroud RM]]
-
[[Category: Dimer]]
+
[[Category: Tochowicz A]]
-
[[Category: Hts complex with peptidic inhibitor]]
+
-
[[Category: Inactive hts conformation]]
+
-
[[Category: Mutant k47a of ht]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.

PDB ID 4fgt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fgt"
Personal tools