4s15

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'''Unreleased structure'''
 
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The entry 4s15 is ON HOLD
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==Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)==
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<StructureSection load='4s15' size='340' side='right'caption='[[4s15]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Huang, P., Santori, F.R., Littman, D.R., Rastinejad, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4s15]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S15 FirstGlance]. <br>
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Description: Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.897&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4D8:(3BETA,4ALPHA,5BETA,14BETA)-3-HYDROXY-4-METHYLCHOLESTA-8,24-DIENE-4-CARBOXYLIC+ACID'>4D8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Santori, F.R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s15 OCA], [https://pdbe.org/4s15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s15 RCSB], [https://www.ebi.ac.uk/pdbsum/4s15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s15 ProSAT]</span></td></tr>
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[[Category: Littman, D.R]]
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</table>
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[[Category: Rastinejad, F]]
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== Function ==
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[[Category: Huang, P]]
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[https://www.uniprot.org/uniprot/RORA_HUMAN RORA_HUMAN] Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.<ref>PMID:9862959</ref> <ref>PMID:11554739</ref> <ref>PMID:11053433</ref> <ref>PMID:14570920</ref> <ref>PMID:15790933</ref> <ref>PMID:15781255</ref> <ref>PMID:17512500</ref> <ref>PMID:18658046</ref> <ref>PMID:18005000</ref> <ref>PMID:12467577</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang P]]
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[[Category: Littman DR]]
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[[Category: Rastinejad F]]
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[[Category: Santori FR]]

Current revision

Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)

PDB ID 4s15

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