2plb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:04, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2plb.gif|left|200px]]
 
-
{{Structure
+
==D(GTATACC) under hydrostatic pressure of 1.39 GPa==
-
|PDB= 2plb |SIZE=350|CAPTION= <scene name='initialview01'>2plb</scene>, resolution 1.60&Aring;
+
<StructureSection load='2plb' size='340' side='right'caption='[[2plb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Spm+Binding+Site+For+Residue+B+20'>AC1</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
+
<table><tr><td colspan='2'>[[2plb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLB FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2plb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plb OCA], [https://pdbe.org/2plb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2plb RCSB], [https://www.ebi.ac.uk/pdbsum/2plb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2plb ProSAT]</span></td></tr>
-
 
+
</table>
-
'''D(GTATACC) under hydrostatic pressure of 1.39 GPa'''
+
<div style="background-color:#fffaf0;">
-
 
+
== Publication Abstract from PubMed ==
-
 
+
-
==Overview==
+
The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
-
==About this Structure==
+
Adaptation of the base-paired double-helix molecular architecture to extreme pressure.,Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642<ref>PMID:17617642</ref>
-
2PLB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA].
+
-
 
+
-
==Reference==
+
-
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642]
+
-
[[Category: Protein complex]]
+
-
[[Category: Fourme, R.]]
+
-
[[Category: Girard, E.]]
+
-
[[Category: Kahn, R.]]
+
-
[[Category: Prange, T.]]
+
-
[[Category: SPM]]
+
-
[[Category: crystal structure]]
+
-
[[Category: dna]]
+
-
[[Category: high-pressure]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:14:25 2008''
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2plb" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Fourme R]]
 +
[[Category: Girard E]]
 +
[[Category: Kahn R]]
 +
[[Category: Prange T]]

Current revision

D(GTATACC) under hydrostatic pressure of 1.39 GPa

PDB ID 2plb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2plb"
Personal tools