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4wxf

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==Crystal structure of L-Serine Hydroxymethyltransferase in complex with glycine==
==Crystal structure of L-Serine Hydroxymethyltransferase in complex with glycine==
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<StructureSection load='4wxf' size='340' side='right' caption='[[4wxf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4wxf' size='340' side='right'caption='[[4wxf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wxf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WXF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wxf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus_CNRZ1066 Streptococcus thermophilus CNRZ1066]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WXF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wxf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wxf RCSB], [http://www.ebi.ac.uk/pdbsum/4wxf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wxf OCA], [https://pdbe.org/4wxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wxf RCSB], [https://www.ebi.ac.uk/pdbsum/4wxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wxf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
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[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4wxf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycine hydroxymethyltransferase]]
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[[Category: Large Structures]]
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[[Category: Bujons, J]]
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[[Category: Streptococcus thermophilus CNRZ1066]]
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[[Category: Clapes, P]]
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[[Category: Bujons J]]
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[[Category: Hernandez, K]]
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[[Category: Clapes P]]
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[[Category: Joglar, J]]
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[[Category: Hernandez K]]
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[[Category: Parella, T]]
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[[Category: Joglar J]]
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[[Category: Petrillo, G]]
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[[Category: Parella T]]
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[[Category: Uson, I]]
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[[Category: Petrillo G]]
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[[Category: Wadtke, C]]
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[[Category: Uson I]]
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[[Category: Zelen, I]]
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[[Category: Wadtke C]]
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[[Category: Aldehyde]]
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[[Category: Zelen I]]
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[[Category: Aldolase]]
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[[Category: Catalysis]]
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[[Category: Catalytic domain]]
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[[Category: Dimerization]]
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[[Category: L-serine hydroxymethyltransferase]]
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[[Category: L-threonine]]
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[[Category: L-threonine aldolase]]
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[[Category: Protein binding]]
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[[Category: Transferase]]
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Current revision

Crystal structure of L-Serine Hydroxymethyltransferase in complex with glycine

PDB ID 4wxf

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