2poy

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[[Image:2poy.jpg|left|200px]]
 
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{{Structure
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==Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A==
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|PDB= 2poy |SIZE=350|CAPTION= <scene name='initialview01'>2poy</scene>, resolution 1.800&Aring;
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<StructureSection load='2poy' size='340' side='right'caption='[[2poy]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2poy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum_Iowa_II Cryptosporidium parvum Iowa II] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2POY FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= cgd2_4120 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353152 Cryptosporidium parvum Iowa II])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2poy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poy OCA], [https://pdbe.org/2poy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2poy RCSB], [https://www.ebi.ac.uk/pdbsum/2poy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2poy ProSAT]</span></td></tr>
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</table>
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'''Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A'''
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== Function ==
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[https://www.uniprot.org/uniprot/A3FQA7_CRYPI A3FQA7_CRYPI] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2POY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum_iowa_ii Cryptosporidium parvum iowa ii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POY OCA].
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Check<jmol>
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[[Category: Cryptosporidium parvum iowa ii]]
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<jmolCheckbox>
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[[Category: Single protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/2poy_consurf.spt"</scriptWhenChecked>
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[[Category: Arrowsmith, C H.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Artz, J D.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Bochkarev, A.]]
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</jmolCheckbox>
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[[Category: Edwards, A M.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2poy ConSurf].
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[[Category: Hassanali, A.]]
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<div style="clear:both"></div>
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[[Category: Hills, T.]]
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__TOC__
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[[Category: Hui, R.]]
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</StructureSection>
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[[Category: Kozieradzki, I.]]
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[[Category: Cryptosporidium parvum Iowa II]]
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[[Category: Lew, J.]]
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[[Category: Large Structures]]
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[[Category: Lin, Y H.]]
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[[Category: Tolypocladium inflatum]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Arrowsmith CH]]
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[[Category: Schapira, M.]]
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[[Category: Artz JD]]
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[[Category: Sundstrom, M.]]
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[[Category: Bochkarev A]]
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[[Category: Weigelt, J.]]
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[[Category: Edwards AM]]
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[[Category: Wernimont, A K.]]
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[[Category: Hassanali A]]
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[[Category: Xiao, T.]]
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[[Category: Hills T]]
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[[Category: Zhao, Y.]]
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[[Category: Hui R]]
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[[Category: cryptosporidium]]
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[[Category: Kozieradzki I]]
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[[Category: cyclophilin]]
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[[Category: Lew J]]
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[[Category: cyclosporin]]
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[[Category: Lin YH]]
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[[Category: parvum]]
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[[Category: Schapira M]]
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[[Category: sgc]]
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[[Category: Sundstrom M]]
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[[Category: structural genomic]]
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[[Category: Weigelt J]]
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[[Category: structural genomics consortium]]
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[[Category: Wernimont AK]]
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[[Category: Xiao T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:15:48 2008''
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[[Category: Zhao Y]]

Current revision

Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A

PDB ID 2poy

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