4xy2
From Proteopedia
(Difference between revisions)
m (Protected "4xy2" [edit=sysop:move=sysop]) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PDE10A in complex with ASP9436== | |
| + | <StructureSection load='4xy2' size='340' side='right'caption='[[4xy2]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4xy2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XY2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=490:1-METHYL-5-(1-METHYL-3-{[4-(1-METHYL-1H-BENZIMIDAZOL-4-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>490</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy2 OCA], [https://pdbe.org/4xy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xy2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | *[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Amano | + | <references/> |
| - | [[Category: Honbou | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Amano Y]] | ||
| + | [[Category: Honbou K]] | ||
Current revision
Crystal structure of PDE10A in complex with ASP9436
| |||||||||||
