4y0g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==beta2 carbohydrate binding module (CBM) of AMP-activated protein kinase (AMPK)== | |
| + | <StructureSection load='4y0g' size='340' side='right'caption='[[4y0g]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4y0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y0G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y0g OCA], [https://pdbe.org/4y0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y0g RCSB], [https://www.ebi.ac.uk/pdbsum/4y0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y0g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Gorman | + | [[Category: Gooley PR]] |
| - | [[Category: Mobbs | + | [[Category: Gorman MA]] |
| - | [[Category: | + | [[Category: Griffin M]] |
| + | [[Category: Mobbs J]] | ||
| + | [[Category: Parker MW]] | ||
Current revision
beta2 carbohydrate binding module (CBM) of AMP-activated protein kinase (AMPK)
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