4wy4
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of autophagic SNARE complex== | ==Crystal structure of autophagic SNARE complex== | ||
| - | <StructureSection load='4wy4' size='340' side='right' caption='[[4wy4]], [[Resolution|resolution]] 1.40Å' scene=''> | + | <StructureSection load='4wy4' size='340' side='right'caption='[[4wy4]], [[Resolution|resolution]] 1.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wy4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WY4 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4wy4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WY4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wy4 OCA], [https://pdbe.org/4wy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wy4 RCSB], [https://www.ebi.ac.uk/pdbsum/4wy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wy4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/SNP29_HUMAN SNP29_HUMAN]] CEDNIK syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/VAMP8_HUMAN VAMP8_HUMAN] SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.<ref>PMID:12130530</ref> <ref>PMID:23217709</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Synaptosomal-associated protein|Synaptosomal-associated protein]] | ||
| + | *[[Syntaxin 3D structures|Syntaxin 3D structures]] | ||
| + | *[[Vesicle-associated membrane protein|Vesicle-associated membrane protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Brunger AT]] |
| - | [[Category: | + | [[Category: Zhao M]] |
| - | + | ||
Current revision
Crystal structure of autophagic SNARE complex
| |||||||||||
