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3mbi

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==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==
==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==
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<StructureSection load='3mbi' size='340' side='right' caption='[[3mbi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3mbi' size='340' side='right'caption='[[3mbi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MBI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MBI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lrt|3lrt]], [[3lpn|3lpn]], [[1u9y|1u9y]], [[1u9z|1u9z]], [[1ibs|1ibs]], [[2hcr|2hcr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 Thermoplasma volcanium])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [https://pdbe.org/3mbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [https://www.ebi.ac.uk/pdbsum/3mbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mbi ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [http://www.ebi.ac.uk/pdbsum/3mbi PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KPRS_THEVO KPRS_THEVO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3mbi" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ribose-phosphate diphosphokinase]]
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[[Category: Large Structures]]
[[Category: Thermoplasma volcanium]]
[[Category: Thermoplasma volcanium]]
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[[Category: Cherney, L T]]
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[[Category: Cherney LT]]
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[[Category: Cherney, M M]]
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[[Category: Cherney MM]]
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[[Category: Garen, C R]]
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[[Category: Garen CR]]
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[[Category: James, M N.G]]
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[[Category: James MNG]]
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[[Category: Atp analog binding]]
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[[Category: Phosphoribosyl transferase]]
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[[Category: Ribose 5-phosphate binding]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate

PDB ID 3mbi

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