4mai

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==Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Cu(I)==
==Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Cu(I)==
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<StructureSection load='4mai' size='340' side='right' caption='[[4mai]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='4mai' size='340' side='right'caption='[[4mai]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspoz Aspoz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MAI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_oryzae Aspergillus oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MAI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mah|4mah]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AO090102000501 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5062 ASPOZ])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mai OCA], [https://pdbe.org/4mai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mai RCSB], [https://www.ebi.ac.uk/pdbsum/4mai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mai ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mai RCSB], [http://www.ebi.ac.uk/pdbsum/4mai PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LP11_ASPOR LP11_ASPOR] Lytic polysaccharide monooxygenase (LPMO) that depolymerizes chitin via the oxidation of scissile beta-(1-4)-glycosidic bonds, yielding C1 or C4 oxidation products (PubMed:24362702). Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate (PubMed:24362702). Active on chitin but has no activity on other substrates, including diverse mannans, cellulose and starch (data not shown) (PubMed:24362702). Primary chain cleavage yields predominantly aldonic acid oligosaccharides with even-numbered degrees of polymerization (PubMed:24362702).<ref>PMID:24362702</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4mai" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspoz]]
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[[Category: Aspergillus oryzae]]
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[[Category: Davies, G J]]
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[[Category: Large Structures]]
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[[Category: Hemsworth, G R]]
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[[Category: Davies GJ]]
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[[Category: Henrissat, B]]
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[[Category: Hemsworth GR]]
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[[Category: Walton, P H]]
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[[Category: Henrissat B]]
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[[Category: Aa11]]
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[[Category: Walton PH]]
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[[Category: Chitin degradation]]
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[[Category: Chitin oxidation]]
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[[Category: Gh61]]
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[[Category: Oxidoreductase]]
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Current revision

Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Cu(I)

PDB ID 4mai

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