This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4n1b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:25, 28 December 2022) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid==
==STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid==
-
<StructureSection load='4n1b' size='340' side='right' caption='[[4n1b]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
+
<StructureSection load='4n1b' size='340' side='right'caption='[[4n1b]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4n1b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N1B FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4n1b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N1B FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FS:(1S,2R)-2-{[(1S)-1-[(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}CYCLOHEXANECARBOXYLIC+ACID'>2FS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FS:(1S,2R)-2-{[(1S)-1-[(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}CYCLOHEXANECARBOXYLIC+ACID'>2FS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7b|4l7b]], [[4l7c|4l7c]], [[4l7d|4l7d]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1b OCA], [https://pdbe.org/4n1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n1b RCSB], [https://www.ebi.ac.uk/pdbsum/4n1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1b ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n1b RCSB], [http://www.ebi.ac.uk/pdbsum/4n1b PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4n1b" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Kelch-like ECH-associated protein 1|Kelch-like ECH-associated protein 1]]
+
*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Albrecht, C]]
+
[[Category: Large Structures]]
-
[[Category: Barker, J]]
+
[[Category: Albrecht C]]
-
[[Category: Barker, O]]
+
[[Category: Barker J]]
-
[[Category: Beaumont, E]]
+
[[Category: Barker O]]
-
[[Category: Bromidge, S]]
+
[[Category: Beaumont E]]
-
[[Category: Brookfield, F]]
+
[[Category: Bromidge S]]
-
[[Category: Brooks, M]]
+
[[Category: Brookfield F]]
-
[[Category: Courade, J P]]
+
[[Category: Brooks M]]
-
[[Category: Duclos, S]]
+
[[Category: Courade JP]]
-
[[Category: Fryatt, T]]
+
[[Category: Duclos S]]
-
[[Category: Jnoff, E]]
+
[[Category: Fryatt T]]
-
[[Category: Kwong, J]]
+
[[Category: Jnoff E]]
-
[[Category: Smith, M A]]
+
[[Category: Kwong J]]
-
[[Category: Beta-propeller]]
+
[[Category: Smith MA]]
-
[[Category: Cytosol]]
+
-
[[Category: Kelch domain]]
+
-
[[Category: Kelch repeat motif]]
+
-
[[Category: Nrf2]]
+
-
[[Category: Protein-small molecule complex]]
+
-
[[Category: Replacement soaking]]
+
-
[[Category: Small molecular binding]]
+
-
[[Category: Stress sensor]]
+
-
[[Category: Transcription-inhibitor complex]]
+

Current revision

STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid

PDB ID 4n1b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4n1b"
Personal tools