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4gmo

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==Crystal structure of Syo1==
==Crystal structure of Syo1==
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<StructureSection load='4gmo' size='340' side='right' caption='[[4gmo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4gmo' size='340' side='right'caption='[[4gmo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gmo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMO FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0033460, Syo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 Chaetomium thermophilum var. thermophilum DSM 1495])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmo RCSB], [http://www.ebi.ac.uk/pdbsum/4gmo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmo OCA], [https://pdbe.org/4gmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmo RCSB], [https://www.ebi.ac.uk/pdbsum/4gmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmo ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G0S5S6_CHATD G0S5S6_CHATD]
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Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic transport with ribosome assembly. Here, we identify a transport adaptor, symportin 1 (Syo1), that facilitates synchronized coimport of the two 5S-rRNA binding proteins Rpl5 and Rpl11. In vitro studies revealed that Syo1 concomitantly binds Rpl5-Rpl11 and furthermore recruits the import receptor Kap104. The Syo1-Rpl5-Rpl11 import complex is released from Kap104 by RanGTP and can be directly transferred onto the 5S rRNA. Syo1 can shuttle back to the cytoplasm by interaction with phenylalanine-glycine nucleoporins. X-ray crystallography uncovered how the alpha-solenoid symportin accommodates the Rpl5 amino terminus, normally bound to 5S rRNA, in an extended groove. Symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes.
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Synchronizing nuclear import of ribosomal proteins with ribosome assembly.,Kressler D, Bange G, Ogawa Y, Stjepanovic G, Bradatsch B, Pratte D, Amlacher S, Strauss D, Yoneda Y, Katahira J, Sinning I, Hurt E Science. 2012 Nov 2;338(6107):666-71. doi: 10.1126/science.1226960. PMID:23118189<ref>PMID:23118189</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chaetomium thermophilum var. thermophilum dsm 1495]]
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
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[[Category: Bange, G]]
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[[Category: Large Structures]]
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[[Category: Sinning, I]]
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[[Category: Bange G]]
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[[Category: Arm]]
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[[Category: Sinning I]]
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[[Category: Chaperone]]
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[[Category: Heat]]
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[[Category: Kap104]]
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[[Category: Nuclear transport]]
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[[Category: Nucleus]]
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[[Category: Rpl11]]
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[[Category: Rpl5]]
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[[Category: Solenoid]]
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Current revision

Crystal structure of Syo1

PDB ID 4gmo

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