4l3f

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==Crystal structure of Internalin K (InlK) from Listeria monocytogenes==
==Crystal structure of Internalin K (InlK) from Listeria monocytogenes==
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<StructureSection load='4l3f' size='340' side='right' caption='[[4l3f]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='4l3f' size='340' side='right'caption='[[4l3f]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l3f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L3F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l3f]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L3F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l3a|4l3a]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lmo1290 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169963 LISMO])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3f OCA], [https://pdbe.org/4l3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l3f RCSB], [https://www.ebi.ac.uk/pdbsum/4l3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l3f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l3f RCSB], [http://www.ebi.ac.uk/pdbsum/4l3f PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8Y7I7_LISMO Q8Y7I7_LISMO]
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Listeria monocytogenes is a human pathogen that employs a wide variety of virulence factors in order to adhere to, invade, and replicate within target cells. Internalins play key roles in processes ranging from adhesion to receptor recognition and are thus essential for infection. Recently, InlK, a surface-associated internalin, was shown to be involved in Listeria's ability to escape from autophagy by recruitment of the major vault protein (MVP) to the bacterial surface. Here, we report the structure of InlK, which harbors four domains arranged in the shape of a "bent arm". The structure supports a role for the "elbow" of InlK in partner recognition, as well as of two Ig-like pedestals intercalated by hinge regions in the projection of InlK away from the surface of the bacterium. The unusual fold and flexibility of InlK could be essential for MVP binding and concealment from recognition by molecules involved in the autophagic process.
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Structure of Internalin InlK from the Human Pathogen Listeriamonocytogenes.,Neves D, Job V, Dortet L, Cossart P, Dessen A J Mol Biol. 2013 Aug 16. pii: S0022-2836(13)00513-5. doi:, 10.1016/j.jmb.2013.08.010. PMID:23958637<ref>PMID:23958637</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lismo]]
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[[Category: Large Structures]]
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[[Category: Neves, D]]
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Cell invasion]]
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[[Category: Neves D]]
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[[Category: Immune system evasion]]
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[[Category: Leucine rich repeat]]
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[[Category: Major vault protein]]
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Current revision

Crystal structure of Internalin K (InlK) from Listeria monocytogenes

PDB ID 4l3f

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