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4l7d

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==Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid==
==Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid==
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<StructureSection load='4l7d' size='340' side='right' caption='[[4l7d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='4l7d' size='340' side='right'caption='[[4l7d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l7d]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L7D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l7d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VX:(1S,2R)-2-{[(1S)-5-METHYL-1-[(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}CYCLOHEXANECARBOXYLIC+ACID'>1VX</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7b|4l7b]], [[4l7c|4l7c]], [[4n1b|4n1b]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VX:(1S,2R)-2-{[(1S)-5-METHYL-1-[(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}CYCLOHEXANECARBOXYLIC+ACID'>1VX</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7d OCA], [https://pdbe.org/4l7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7d RCSB], [https://www.ebi.ac.uk/pdbsum/4l7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7d RCSB], [http://www.ebi.ac.uk/pdbsum/4l7d PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4l7d" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Kelch-like ECH-associated protein 1|Kelch-like ECH-associated protein 1]]
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*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Albrecht, C]]
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[[Category: Large Structures]]
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[[Category: Barker, J J]]
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[[Category: Albrecht C]]
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[[Category: Barker, O]]
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[[Category: Barker JJ]]
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[[Category: Beaumont, E]]
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[[Category: Barker O]]
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[[Category: Bromidge, S]]
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[[Category: Beaumont E]]
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[[Category: Brookfield, F]]
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[[Category: Bromidge S]]
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[[Category: Brooks, M]]
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[[Category: Brookfield F]]
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[[Category: Ceska, T]]
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[[Category: Brooks M]]
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[[Category: Courade, J P]]
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[[Category: Ceska T]]
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[[Category: Crabbe, T]]
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[[Category: Courade JP]]
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[[Category: Duclos, S]]
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[[Category: Crabbe T]]
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[[Category: Fryatt, T]]
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[[Category: Duclos S]]
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[[Category: Jigorel, E]]
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[[Category: Fryatt T]]
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[[Category: Jnoff, E]]
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[[Category: Jigorel E]]
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[[Category: Kwong, J]]
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[[Category: Jnoff E]]
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[[Category: Sands, Z]]
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[[Category: Kwong J]]
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[[Category: Smith, M A]]
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[[Category: Sands Z]]
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[[Category: Beta-propeller]]
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[[Category: Smith MA]]
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[[Category: Kelch domain]]
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[[Category: Kelch repeat motif]]
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[[Category: Nrf2]]
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[[Category: Protein-small molecule complex]]
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[[Category: Stress sensor]]
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[[Category: Transcription-inhibitor complex]]
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Current revision

Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid

PDB ID 4l7d

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