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4oud

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==Engineered tyrosyl-tRNA synthetase with the nonstandard amino acid L-4,4-biphenylalanine==
==Engineered tyrosyl-tRNA synthetase with the nonstandard amino acid L-4,4-biphenylalanine==
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<StructureSection load='4oud' size='340' side='right' caption='[[4oud]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='4oud' size='340' side='right'caption='[[4oud]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oud]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OUD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MC4100 Escherichia coli str. K-12 substr. MC4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OUD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIF:(R)-2-AMINO-3-(4-PHENYLCYCLOHEXYL)PROPANOIC+ACID'>BIF</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIF:(R)-2-AMINO-3-(4-PHENYLCYCLOHEXYL)PROPANOIC+ACID'>BIF</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oud OCA], [https://pdbe.org/4oud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oud RCSB], [https://www.ebi.ac.uk/pdbsum/4oud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oud ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oud RCSB], [http://www.ebi.ac.uk/pdbsum/4oud PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/U6N9P2_ECOLI U6N9P2_ECOLI]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).[HAMAP-Rule:MF_02006][SAAS:SAAS00105801]
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[https://www.uniprot.org/uniprot/A0A0H2UKY9_ECOLI A0A0H2UKY9_ECOLI] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).[HAMAP-Rule:MF_02006]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4oud" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Escherichia coli str. K-12 substr. MC4100]]
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[[Category: Church, G M]]
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[[Category: Large Structures]]
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[[Category: Lajoie, M J]]
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[[Category: Church GM]]
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[[Category: Mandell, D J]]
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[[Category: Lajoie MJ]]
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[[Category: Stoddard, B L]]
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[[Category: Mandell DJ]]
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[[Category: Takeuchi, R]]
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[[Category: Stoddard BL]]
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[[Category: Complex with l-tyrosine]]
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[[Category: Takeuchi R]]
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[[Category: Ligase]]
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[[Category: Rossmann fold]]
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[[Category: Trna]]
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Current revision

Engineered tyrosyl-tRNA synthetase with the nonstandard amino acid L-4,4-biphenylalanine

PDB ID 4oud

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