2mz1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of hnRNP C RRM in complex with 5'-UUUUC-3' RNA== | |
| - | + | <StructureSection load='2mz1' size='340' side='right'caption='[[2mz1]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz1 OCA], [https://pdbe.org/2mz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz1 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Allain | + | [https://www.uniprot.org/uniprot/HNRPC_HUMAN HNRPC_HUMAN] Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.<ref>PMID:8264621</ref> <ref>PMID:7567451</ref> <ref>PMID:12509468</ref> <ref>PMID:16010978</ref> |
| - | [[Category: Damberger | + | == References == |
| - | [[Category: Maris | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Allain FH-T]] | ||
| + | [[Category: Cienikova Z]] | ||
| + | [[Category: Damberger FF]] | ||
| + | [[Category: Hall J]] | ||
| + | [[Category: Maris C]] | ||
Current revision
Solution structure of hnRNP C RRM in complex with 5'-UUUUC-3' RNA
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