2q1z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:13, 21 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2q1z.gif|left|200px]]
 
-
{{Structure
+
==Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR==
-
|PDB= 2q1z |SIZE=350|CAPTION= <scene name='initialview01'>2q1z</scene>, resolution 2.40&Aring;
+
<StructureSection load='2q1z' size='340' side='right'caption='[[2q1z]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[2q1z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q1Z FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
|GENE= rpoE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1063 Rhodobacter sphaeroides]), chrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1063 Rhodobacter sphaeroides])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q1z OCA], [https://pdbe.org/2q1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q1z RCSB], [https://www.ebi.ac.uk/pdbsum/2q1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q1z ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/RPOE_CERS4 RPOE_CERS4] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released. Sigma-E controls a transcriptional response to singlet oxygen, a by-product of photosynthesis; its continuous activity requires constant exposure to singlet oxygen. The regulon has about 180 genes that protect against or repair damage induced by singlet oxygen, including itself and rpoH2, a heat shock-responsive sigma factor.<ref>PMID:11676534</ref> <ref>PMID:15855269</ref> <ref>PMID:17803943</ref>
-
 
+
== Evolutionary Conservation ==
-
==Overview==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
A transcriptional response to singlet oxygen in Rhodobacter sphaeroides is controlled by the group IV sigma factor sigma(E) and its cognate anti-sigma ChrR. Crystal structures of the sigma(E)/ChrR complex reveal a modular, two-domain architecture for ChrR. The ChrR N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is required for the transcriptional response to singlet oxygen. Structure-based sequence analyses predict that the ASD defines a common structural fold among predicted group IV anti-sigmas. These ASDs are fused to diverse C-terminal domains that are likely involved in responding to specific environmental signals that control the activity of their cognate sigma factor.
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/2q1z_consurf.spt"</scriptWhenChecked>
-
2Q1Z is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1Z OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Reference==
+
</jmolCheckbox>
-
A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria., Campbell EA, Greenwell R, Anthony JR, Wang S, Lim L, Das K, Sofia HJ, Donohue TJ, Darst SA, Mol Cell. 2007 Sep 7;27(5):793-805. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17803943 17803943]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q1z ConSurf].
-
[[Category: Protein complex]]
+
<div style="clear:both"></div>
-
[[Category: Rhodobacter sphaeroides]]
+
== References ==
-
[[Category: Campbell, E A.]]
+
<references/>
-
[[Category: Darst, S A.]]
+
__TOC__
-
[[Category: ZN]]
+
</StructureSection>
-
[[Category: anti-sigma factor]]
+
[[Category: Cereibacter sphaeroides 2 4.1]]
-
[[Category: cupin fold]]
+
[[Category: Large Structures]]
-
[[Category: ecf sigma factor]]
+
[[Category: Campbell EA]]
-
[[Category: zinc binding transcription factor]]
+
[[Category: Darst SA]]
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:20:40 2008''
+

Current revision

Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR

PDB ID 2q1z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2q1z"
Personal tools